The association between severely deranged vital signs and Dysglycaemia in severely ill children admitted to Queen Elizabeth Central Hospital (QECH), Blantyre Malawi
Abnormal blood glucose level commonly occurs in children presenting to the hospitals in low income settings. The presence of low blood glucose levels could be a marker of disease severity. Vital signs are routinely checked in sick children and most settings use a combination of deranged vital sig...
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| Format: | Thesis |
| Language: | English |
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Kamuzu University of Health Sciences
2022
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| Online Access: | http://nkhokwe.kuhes.ac.mw/handle/20.500.12845/639 |
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| author | Mayani, Ednas Billiat |
| author_facet | Mayani, Ednas Billiat |
| author_sort | Mayani, Ednas Billiat |
| collection | DSpace |
| description | Abnormal blood glucose level commonly occurs in children presenting to the hospitals in low
income settings. The presence of low blood glucose levels could be a marker of disease severity.
Vital signs are routinely checked in sick children and most settings use a combination of
deranged vital signs to determine disease severity. Blood glucose is a quick, bed side test and
could serve as a complementary indicator of disease severity in low resource settings. The study
aims to determine the association between the presence of severely deranged vital signs and
dysglycaemia in severely ill children admitted to a tertiary hospital in Malawi. This was a crosssectional
study which used secondary data from Paediatric department collected from December
2016 to January 2019. Multinomial logistic regression was used to determine the association
between severely deranged vital signs and dysglycaemia. A total of 5247 children, aged 0 to
18years were recruited into the study. 353(6.7%) had lowglycaemia,105(2.0%) had
hypoglycaemia and 771(14.7%) had hyperglycaemia. The presence of any severely deranged
vital sign, specifically, hypoxia (oxygen saturation <90%) and coma score of<2 were associated
with both hypoglycaemia and hyperglycaemia. The Adjusted Odds Ratio (AOR) for the
association of any severely deranged vital sign with hypoglycaemia was 1.76(95% CI 1.2–2.6)
and 1.5(95% CI 1.3–1.8) with hyperglycaemia. Hypoxia had odds ratio of 2.0(95% CI 1.2–3.4)
for hypoglycaemia and 1.5 (95% CI 1.2–1.9) for hyperglycaemia whilst for reduced coma score
the odds was 6.5(95% CI 4.2–10.2) and 2.3(95% CI 1.8–2.9) respectively.
The results have shown that the presence of any severely deranged vital sign is associated with
dysglycaemia especially hypoglycaemia and hyperglycaemia. As such dysglycaemia might be
used as a complementary marker of disease severity in low resource settings. |
| format | Thesis |
| id | oai:nkhokwe.kuhes.ac.mw:20.500.12845-639 |
| institution | My University |
| language | English |
| publishDate | 2022 |
| publisher | Kamuzu University of Health Sciences |
| record_format | dspace |
| spelling | oai:nkhokwe.kuhes.ac.mw:20.500.12845-6392023-03-12T00:01:14Z The association between severely deranged vital signs and Dysglycaemia in severely ill children admitted to Queen Elizabeth Central Hospital (QECH), Blantyre Malawi Mayani, Ednas Billiat Abnormal blood glucose level commonly occurs in children presenting to the hospitals in low income settings. The presence of low blood glucose levels could be a marker of disease severity. Vital signs are routinely checked in sick children and most settings use a combination of deranged vital signs to determine disease severity. Blood glucose is a quick, bed side test and could serve as a complementary indicator of disease severity in low resource settings. The study aims to determine the association between the presence of severely deranged vital signs and dysglycaemia in severely ill children admitted to a tertiary hospital in Malawi. This was a crosssectional study which used secondary data from Paediatric department collected from December 2016 to January 2019. Multinomial logistic regression was used to determine the association between severely deranged vital signs and dysglycaemia. A total of 5247 children, aged 0 to 18years were recruited into the study. 353(6.7%) had lowglycaemia,105(2.0%) had hypoglycaemia and 771(14.7%) had hyperglycaemia. The presence of any severely deranged vital sign, specifically, hypoxia (oxygen saturation <90%) and coma score of<2 were associated with both hypoglycaemia and hyperglycaemia. The Adjusted Odds Ratio (AOR) for the association of any severely deranged vital sign with hypoglycaemia was 1.76(95% CI 1.2–2.6) and 1.5(95% CI 1.3–1.8) with hyperglycaemia. Hypoxia had odds ratio of 2.0(95% CI 1.2–3.4) for hypoglycaemia and 1.5 (95% CI 1.2–1.9) for hyperglycaemia whilst for reduced coma score the odds was 6.5(95% CI 4.2–10.2) and 2.3(95% CI 1.8–2.9) respectively. The results have shown that the presence of any severely deranged vital sign is associated with dysglycaemia especially hypoglycaemia and hyperglycaemia. As such dysglycaemia might be used as a complementary marker of disease severity in low resource settings. 2022-05-13T15:56:21Z 2022-05-13T15:56:21Z 2021-07-01 Thesis http://nkhokwe.kuhes.ac.mw/handle/20.500.12845/639 en application/pdf Kamuzu University of Health Sciences |
| spellingShingle | Mayani, Ednas Billiat The association between severely deranged vital signs and Dysglycaemia in severely ill children admitted to Queen Elizabeth Central Hospital (QECH), Blantyre Malawi |
| title | The association between severely deranged vital signs and Dysglycaemia in severely ill children admitted to Queen Elizabeth Central Hospital (QECH), Blantyre Malawi |
| title_full | The association between severely deranged vital signs and Dysglycaemia in severely ill children admitted to Queen Elizabeth Central Hospital (QECH), Blantyre Malawi |
| title_fullStr | The association between severely deranged vital signs and Dysglycaemia in severely ill children admitted to Queen Elizabeth Central Hospital (QECH), Blantyre Malawi |
| title_full_unstemmed | The association between severely deranged vital signs and Dysglycaemia in severely ill children admitted to Queen Elizabeth Central Hospital (QECH), Blantyre Malawi |
| title_short | The association between severely deranged vital signs and Dysglycaemia in severely ill children admitted to Queen Elizabeth Central Hospital (QECH), Blantyre Malawi |
| title_sort | association between severely deranged vital signs and dysglycaemia in severely ill children admitted to queen elizabeth central hospital (qech), blantyre malawi |
| url | http://nkhokwe.kuhes.ac.mw/handle/20.500.12845/639 |
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